Biological features of blood lymphocytes of the primary patients with endometrial cancer

The aim: to examine the radiosensitivity of chromosomes T-lymphocytes in blood primary patients with endometrial cancer depending on radiation dose. It was expected that investigations would reveal a cytogenetic parameter as predictor non-malignant cells exposed curative irradiation.
 Materials and methods. Blood samples from 20 30 conditionally healthy donors were examined. Peripheral culture test system metaphase chromosome aberration analysis used. X-ray test-irradiation performed at G0-stage cell cycle dose range 0.5–3.0 Gy.
 Results. shown spontaneous level aberrations lymphocytes before anti-tumour therapy is 7,82±0,33 aberrations/100 metaphases. This more than 2-fold higher upper limit average population index approximately 6-fold data own control. In our study during irradiation cultures patients, it found for first time total frequency radiation-induced obeys classical linear quadratic dependence predominance component values; markers – also dependence, but component.
 Conclusions. High specificity T-lymphocyte exposure ionizing well strict yield justify their use predictors tumour environment. revealed dependences induction chromosomal damage prove need personalized approach plan course